Hazardous effects of octopamine receptor agonists on altering metabolism-related genes and behavior of Drosophila melanogaster.
Identifieur interne : 000143 ( Main/Exploration ); précédent : 000142; suivant : 000144Hazardous effects of octopamine receptor agonists on altering metabolism-related genes and behavior of Drosophila melanogaster.
Auteurs : Mohamed Ahmed Ibrahim Ahmed [États-Unis] ; Christoph Franz Adam Vogel [États-Unis]Source :
- Chemosphere [ 1879-1298 ] ; 2020.
Descripteurs français
- KwdFr :
- Amidines (MeSH), Animaux (MeSH), Comportement animal (MeSH), Drosophila melanogaster (effets des médicaments et des substances chimiques), Drosophila melanogaster (physiologie), Femelle (MeSH), Mâle (MeSH), Métabolisme (génétique), Octopamine (toxicité), Protéine-7 associée à l'autophagie (MeSH), Protéines de Drosophila (génétique), Récepteurs aux amines biogéniques (MeSH), Toluidines (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Drosophila melanogaster.
- génétique : Métabolisme, Protéines de Drosophila.
- physiologie : Drosophila melanogaster.
- toxicité : Octopamine.
- Amidines, Animaux, Comportement animal, Femelle, Mâle, Protéine-7 associée à l'autophagie, Récepteurs aux amines biogéniques, Toluidines.
English descriptors
- KwdEn :
- Amidines (MeSH), Animals (MeSH), Autophagy-Related Protein 7 (MeSH), Behavior, Animal (MeSH), Drosophila Proteins (genetics), Drosophila melanogaster (drug effects), Drosophila melanogaster (physiology), Female (MeSH), Male (MeSH), Metabolism (genetics), Octopamine (toxicity), Receptors, Biogenic Amine (MeSH), Toluidines (MeSH).
- MESH :
- chemical , genetics : Drosophila Proteins.
- chemical , toxicity : Octopamine.
- chemical : Amidines, Autophagy-Related Protein 7, Receptors, Biogenic Amine, Toluidines.
- drug effects : Drosophila melanogaster.
- genetics : Metabolism.
- physiology : Drosophila melanogaster.
- Animals, Behavior, Animal, Female, Male.
Abstract
Recent reports demonstrate that octopamine receptor (OR) agonists such as formamidine pesticides cause reproductive and developmental toxicity through endocrine disrupting effects in both humans and animals. Herein, we studied the effects of different sublethal concentrations of OR agonists, Amitraz and Chlordimeform, on growth, development, and reproduction of D. melanogaster from a genotype perspective view. As a result, the sublethal concentrations for both OR agonists delayed the developmental time including pupation and eclosion. It significantly reduced the lifespan, eclosion rate, and production of eggs. The mRNA expression of genes relevant for development and metabolism was significantly changed after exposure to sublethal concentrations of both OR agonists. Octopamine receptor in mushroom bodies (Oamb), trehalase enzyme (Treh), hemocyte proliferation (RyR), and immune response (IM4) genes were upregulated whereas, trehalose sugar (Tret1-1), mixed function oxidase enzyme (Cyp9f2), lifespan (Atg7), male mating behavior (Ple), female fertility (Ddc), and lipid metabolism (Sxe2) genes were downregulated. These results support the conclusion that OR agonists activate the octopamine receptor in D. melanogaster leading to an increase of trehalase enzyme activity and degradation of trehalose sugar into free glucose which results in rapid energy exhaustion, hyperexcitation, and disturbing of the octopaminergic system in D. melanogaster.
DOI: 10.1016/j.chemosphere.2020.126629
PubMed: 32283422
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hazardous effects of octopamine receptor agonists on altering metabolism-related genes and behavior of Drosophila melanogaster.</title><author><name sortKey="Ahmed, Mohamed Ahmed Ibrahim" sort="Ahmed, Mohamed Ahmed Ibrahim" uniqKey="Ahmed M" first="Mohamed Ahmed Ibrahim" last="Ahmed">Mohamed Ahmed Ibrahim Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>Plant Protection Department, Faculty of Agriculture, Assiut University, Assiut, 71526, Egypt; Center for Health and the Environment, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Plant Protection Department, Faculty of Agriculture, Assiut University, Assiut, 71526, Egypt; Center for Health and the Environment</wicri:regionArea><wicri:noRegion>Egypt; Center for Health and the Environment</wicri:noRegion></affiliation></author><author><name sortKey="Vogel, Christoph Franz Adam" sort="Vogel, Christoph Franz Adam" uniqKey="Vogel C" first="Christoph Franz Adam" last="Vogel">Christoph Franz Adam Vogel</name><affiliation wicri:level="1"><nlm:affiliation>Center for Health and the Environment, USA; Department of Environmental Toxicology, University of California, Davis, CA, 95616, USA. Electronic address: cfvogel@ucdavis.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Health and the Environment, USA; Department of Environmental Toxicology, University of California, Davis, CA, 95616</wicri:regionArea><wicri:noRegion>95616</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32283422</idno><idno type="pmid">32283422</idno><idno type="doi">10.1016/j.chemosphere.2020.126629</idno><idno type="wicri:Area/Main/Corpus">000164</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000164</idno><idno type="wicri:Area/Main/Curation">000164</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000164</idno><idno type="wicri:Area/Main/Exploration">000164</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hazardous effects of octopamine receptor agonists on altering metabolism-related genes and behavior of Drosophila melanogaster.</title><author><name sortKey="Ahmed, Mohamed Ahmed Ibrahim" sort="Ahmed, Mohamed Ahmed Ibrahim" uniqKey="Ahmed M" first="Mohamed Ahmed Ibrahim" last="Ahmed">Mohamed Ahmed Ibrahim Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>Plant Protection Department, Faculty of Agriculture, Assiut University, Assiut, 71526, Egypt; Center for Health and the Environment, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Plant Protection Department, Faculty of Agriculture, Assiut University, Assiut, 71526, Egypt; Center for Health and the Environment</wicri:regionArea><wicri:noRegion>Egypt; Center for Health and the Environment</wicri:noRegion></affiliation></author><author><name sortKey="Vogel, Christoph Franz Adam" sort="Vogel, Christoph Franz Adam" uniqKey="Vogel C" first="Christoph Franz Adam" last="Vogel">Christoph Franz Adam Vogel</name><affiliation wicri:level="1"><nlm:affiliation>Center for Health and the Environment, USA; Department of Environmental Toxicology, University of California, Davis, CA, 95616, USA. Electronic address: cfvogel@ucdavis.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Health and the Environment, USA; Department of Environmental Toxicology, University of California, Davis, CA, 95616</wicri:regionArea><wicri:noRegion>95616</wicri:noRegion></affiliation></author></analytic><series><title level="j">Chemosphere</title><idno type="eISSN">1879-1298</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amidines (MeSH)</term><term>Animals (MeSH)</term><term>Autophagy-Related Protein 7 (MeSH)</term><term>Behavior, Animal (MeSH)</term><term>Drosophila Proteins (genetics)</term><term>Drosophila melanogaster (drug effects)</term><term>Drosophila melanogaster (physiology)</term><term>Female (MeSH)</term><term>Male (MeSH)</term><term>Metabolism (genetics)</term><term>Octopamine (toxicity)</term><term>Receptors, Biogenic Amine (MeSH)</term><term>Toluidines (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amidines (MeSH)</term><term>Animaux (MeSH)</term><term>Comportement animal (MeSH)</term><term>Drosophila melanogaster (effets des médicaments et des substances chimiques)</term><term>Drosophila melanogaster (physiologie)</term><term>Femelle (MeSH)</term><term>Mâle (MeSH)</term><term>Métabolisme (génétique)</term><term>Octopamine (toxicité)</term><term>Protéine-7 associée à l'autophagie (MeSH)</term><term>Protéines de Drosophila (génétique)</term><term>Récepteurs aux amines biogéniques (MeSH)</term><term>Toluidines (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Drosophila Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Octopamine</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Amidines</term><term>Autophagy-Related Protein 7</term><term>Receptors, Biogenic Amine</term><term>Toluidines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Drosophila melanogaster</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Drosophila melanogaster</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Metabolism</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Métabolisme</term><term>Protéines de Drosophila</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Drosophila melanogaster</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Drosophila melanogaster</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Octopamine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Behavior, Animal</term><term>Female</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Amidines</term><term>Animaux</term><term>Comportement animal</term><term>Femelle</term><term>Mâle</term><term>Protéine-7 associée à l'autophagie</term><term>Récepteurs aux amines biogéniques</term><term>Toluidines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent reports demonstrate that octopamine receptor (OR) agonists such as formamidine pesticides cause reproductive and developmental toxicity through endocrine disrupting effects in both humans and animals. Herein, we studied the effects of different sublethal concentrations of OR agonists, Amitraz and Chlordimeform, on growth, development, and reproduction of D. melanogaster from a genotype perspective view. As a result, the sublethal concentrations for both OR agonists delayed the developmental time including pupation and eclosion. It significantly reduced the lifespan, eclosion rate, and production of eggs. The mRNA expression of genes relevant for development and metabolism was significantly changed after exposure to sublethal concentrations of both OR agonists. Octopamine receptor in mushroom bodies (Oamb), trehalase enzyme (Treh), hemocyte proliferation (RyR), and immune response (IM4) genes were upregulated whereas, trehalose sugar (Tret1-1), mixed function oxidase enzyme (Cyp9f2), lifespan (Atg7), male mating behavior (Ple), female fertility (Ddc), and lipid metabolism (Sxe2) genes were downregulated. These results support the conclusion that OR agonists activate the octopamine receptor in D. melanogaster leading to an increase of trehalase enzyme activity and degradation of trehalose sugar into free glucose which results in rapid energy exhaustion, hyperexcitation, and disturbing of the octopaminergic system in D. melanogaster.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32283422</PMID><DateCompleted><Year>2020</Year><Month>06</Month><Day>24</Day></DateCompleted><DateRevised><Year>2020</Year><Month>06</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1298</ISSN><JournalIssue CitedMedium="Internet"><Volume>253</Volume><PubDate><Year>2020</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Chemosphere</Title><ISOAbbreviation>Chemosphere</ISOAbbreviation></Journal><ArticleTitle>Hazardous effects of octopamine receptor agonists on altering metabolism-related genes and behavior of Drosophila melanogaster.</ArticleTitle><Pagination><MedlinePgn>126629</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0045-6535(20)30822-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.chemosphere.2020.126629</ELocationID><Abstract><AbstractText>Recent reports demonstrate that octopamine receptor (OR) agonists such as formamidine pesticides cause reproductive and developmental toxicity through endocrine disrupting effects in both humans and animals. Herein, we studied the effects of different sublethal concentrations of OR agonists, Amitraz and Chlordimeform, on growth, development, and reproduction of D. melanogaster from a genotype perspective view. As a result, the sublethal concentrations for both OR agonists delayed the developmental time including pupation and eclosion. It significantly reduced the lifespan, eclosion rate, and production of eggs. The mRNA expression of genes relevant for development and metabolism was significantly changed after exposure to sublethal concentrations of both OR agonists. Octopamine receptor in mushroom bodies (Oamb), trehalase enzyme (Treh), hemocyte proliferation (RyR), and immune response (IM4) genes were upregulated whereas, trehalose sugar (Tret1-1), mixed function oxidase enzyme (Cyp9f2), lifespan (Atg7), male mating behavior (Ple), female fertility (Ddc), and lipid metabolism (Sxe2) genes were downregulated. These results support the conclusion that OR agonists activate the octopamine receptor in D. melanogaster leading to an increase of trehalase enzyme activity and degradation of trehalose sugar into free glucose which results in rapid energy exhaustion, hyperexcitation, and disturbing of the octopaminergic system in D. melanogaster.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Mohamed Ahmed Ibrahim</ForeName><Initials>MAI</Initials><AffiliationInfo><Affiliation>Plant Protection Department, Faculty of Agriculture, Assiut University, Assiut, 71526, Egypt; Center for Health and the Environment, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vogel</LastName><ForeName>Christoph Franz Adam</ForeName><Initials>CFA</Initials><AffiliationInfo><Affiliation>Center for Health and the Environment, USA; Department of Environmental Toxicology, University of California, Davis, CA, 95616, USA. Electronic address: cfvogel@ucdavis.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Chemosphere</MedlineTA><NlmUniqueID>0320657</NlmUniqueID><ISSNLinking>0045-6535</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000578">Amidines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C530193">Atg7 protein, Drosophila</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029721">Drosophila Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017982">Receptors, Biogenic Amine</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014052">Toluidines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C027604">norsynephrine receptor</NameOfSubstance></Chemical><Chemical><RegistryNumber>14O50WS8JD</RegistryNumber><NameOfSubstance UI="D009655">Octopamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>33IAH5017S</RegistryNumber><NameOfSubstance UI="C014983">amitraz</NameOfSubstance></Chemical><Chemical><RegistryNumber>463-52-5</RegistryNumber><NameOfSubstance UI="C077922">formamidine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 6.2.1.45</RegistryNumber><NameOfSubstance UI="D000071193">Autophagy-Related Protein 7</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000578" MajorTopicYN="N">Amidines</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000071193" MajorTopicYN="N">Autophagy-Related Protein 7</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001522" MajorTopicYN="N">Behavior, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D029721" MajorTopicYN="N">Drosophila Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004331" MajorTopicYN="N">Drosophila melanogaster</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008660" MajorTopicYN="N">Metabolism</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009655" MajorTopicYN="N">Octopamine</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017982" MajorTopicYN="N">Receptors, Biogenic Amine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014052" MajorTopicYN="N">Toluidines</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Drosophila melanogaster</Keyword><Keyword MajorTopicYN="N">Formamidines</Keyword><Keyword MajorTopicYN="N">Octopamine receptor agonists (OR agonists)</Keyword><Keyword MajorTopicYN="N">Pesticides</Keyword><Keyword MajorTopicYN="N">Sublethal toxicity</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>01</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>03</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>6</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32283422</ArticleId><ArticleId IdType="pii">S0045-6535(20)30822-5</ArticleId><ArticleId IdType="doi">10.1016/j.chemosphere.2020.126629</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Ahmed, Mohamed Ahmed Ibrahim" sort="Ahmed, Mohamed Ahmed Ibrahim" uniqKey="Ahmed M" first="Mohamed Ahmed Ibrahim" last="Ahmed">Mohamed Ahmed Ibrahim Ahmed</name></noRegion><name sortKey="Vogel, Christoph Franz Adam" sort="Vogel, Christoph Franz Adam" uniqKey="Vogel C" first="Christoph Franz Adam" last="Vogel">Christoph Franz Adam Vogel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PlantImRecepV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000143 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000143 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PlantImRecepV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32283422
|texte= Hazardous effects of octopamine receptor agonists on altering metabolism-related genes and behavior of Drosophila melanogaster.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32283422" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PlantImRecepV1
| This area was generated with Dilib version V0.6.38. |  |